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EXOSOME-BASED SKIN TREATMENT
EXOSOMES
Exosomes are natural nano-sized bilayer lipid vesicles, that are released from different cell types for intercellular, inter-species, and interkingdom communications.
Natural exosomes can be categorized into ADEs (animal-derived-exosomes) and PELNs (plant-derived-exosome-like nanoparticles).
Exosomes can deliver a variety of bioactive substances such as proteins, nucleic acids, lipids, and metabolites.
They safely transfer these substances to target cells, enabling participation in various processes such as tissues repair.
Plant-derived exosomes are also considered safer than artificial nanocarriers.
Plant-derived exosomes are becoming effective therapeutic modalities for treating diseases thanks to their phenomenal intrinsic properties and known minimal side-effects.
provided by nature
provided by nature
phospholipid-rich characteristics
phospholipid-rich characteristics
natural mechanism of cellular uptake
natural mechanism of cellular uptake
tolerated by the immune system
tolerated by the immune system
verified high biocompatibility
verified high biocompatibility
non-toxic
non-toxic
Vegetal exosomes are a better alternative to animal and human-derived exosomes owing to their:
PLANT-DERIVED EXOSOMES FEATURE THE ADVANTAGES OF ANIMAL- AND HUMAN-FREE HEALTH ISSUES.
Dermal penetration
Once exosomes are topically applied to the skin they will easily penetrate via a “lipid-rich channel” coating.
Studies performed on plant-derived exosomes demonstrate that they can increase the dermal penetration efficacy of a lipophilic active ingredient surrogate by approximately 214%, while having a penetration of about 200% more than the controls.
SCT = stratum corneum thickness
APA = amount penetrated AI-surrogate
MPD = mean penetration depth
AI: Active Ingredient
PELNs: Plant Exosome Like Nanoparticles
INCREASES BOTH EXTRACELLULAR AND INTRACELLULAR COLLAGEN LEVELS. HAS A STRONG AND NATURAL ANTI-WRINKLE AND ELASTICIZING EFFECT. HAS A STRONG ANTIOXIDANT ACTION.
Quantification of the bioactive compounds containedin our exosomes mix is reported in the following table:
What is AUMMP
AUMMP is a mix of exosomes from Italian organic agriculture-derived fruits that contains many bioactive compounds. Our mix contains: Orange (A), Grape (U), Pomegranate (M), Mandarin (M) and Papaya (P).
KARISMA Exo Care
Bioactive Anti-age Serum
The anti-age serum, thanks to its active ingredients, is the ideal home treatment for maintaining the results achieved with KARISMA Rh Collagen® injection.
The KARISMA Exo Care – Bioactive Anti-Age Serum acts on increasing the proliferation of fibroblasts, in reducing cell duplication time and in reducing oxidative stress, counteracting the overall effects of skin aging.
The main active ingredients of the serum are:
- Plant-derived exosome mix (from Italian organic agriculture)
- Sodium Hyaluronate (mixture of three molecular weights)
- Mix of Biomimetical Peptides
- Glycerin
KARISMA Exo Care
Bioactive Cream
The cream is an essential component of the home treatment, enhancing the effects of both the anti-aging serum and the injection treatment with KARISMA Rh Collagen®.
The KARISMA Exo-Care – Bioactive Cream is formulated with a pool of selected active ingredients designed to nourish and protect the skin during all day long.
The main active ingredients of the cream are:
- Plant-derived exosome mix (from Italian organic agriculture)
- Sodium Hyaluronate (mixture of three molecular weights)
- Glycolic Acid
- Mix of Biomimetical Peptides
- Vitamin E
- Vitamin A
KARISMA Exo Care
Natural Kernels Scrub System
The KARISMA Exo Care – Natural Kernels Scrub System is the optimal pre-treatment, to be carried out in the evening, before applying the serum and cream that are functionalized with exosomes.
Skin exfoliation occurs on two levels: mechanical thanks to the fruit stone granules, and chemical due to the presence of AHAs absorbed on these granules.
The main active ingredients of the scrub are:
- Glycolic Acid
- Mandelic Acid
- Argan Oil
- Sweet Almond Oil
- Glycerin
KARISMA Exo Care
Complete Skin Care Set
This reference is the optimal solution for those who wish to purchase the complete cosmetic line, at an absolutely advantageous price.
The box contains all the three references of the cosmetic line:
- Bioactive Anti-Age Serum
- Bioactive Cream
- Natural Kernels Scrub System
